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I was diagnosed with Restless Legs Syndrome back in the '90's. I was first prescribed levodopa/carbidopa and it was wonderful at first. However it started losing effectiveness and making me sick during the day at times. Then a new medicine came out- Mirapex and I was put on it at 0.25mg before bedtime. It worked well for several years but had to be upped to 0.5mg. I found that Mirapex controlled my RLS fairly well and I was on it for 12 years! The last year I forced myself to cut back to 0.25mg again and put up with some symptoms. Then, I recently stopped taking it altogether. I have been taking strong vitamin supplements, but they didn't stop the RLS. However, when I started taking Magnesium, Potassium, and Calcium, and bathing in bath salts the RLS has disappeared.
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Propping the feet up higher than the torso may also help.

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Edinburgh (Scotland): Scottish Intercollegiate Guidelines Network (SIGN); 2010 Jan.

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Cases of retroperitoneal fibrosis, pulmonary infiltrates, pleural effusion, pleural thickening, pericarditis, and cardiac valvulopathy have been reported in patients treated with ergot-derived dopaminergic agents.

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Levodopa can also be combined with benserazide (Madopar) with similar results, but Sinemet is almost always used in America.

Do not crush, chew, or break an extended-release tablet (Mirapex ER).

Joints appear swollen, are stiff and painful, and usually feel worse the more they are used throughout the day.

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Speech and language therapy - improving loudness and intelligibility of speech where possible, ensuring methods of communication are available as the disease progresses and to help with swallowing (reducing risk of aspiration).

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If you are using hormonal contraceptives, you should know that this type of birth control may not work well when used with oxcarbazepine.

Pramipexole has some of the same effects as a chemical called dopamine, which occurs naturally in your body.

Although the drug does provide some symptomatic relief, there is no clear evidence from this study that it offers any neuroprotection.

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Pramipexole is also used to treat Restless Legs Syndrome (RLS).

Several case reports and studies involving both children and adults have provided support for the use of oral iron therapy, parenteral iron therapy, or both in the treatment of RLS.

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European guidelines on management of restless legs syndrome: report of a joint task force by the European Federation of Neurological Societies, the European Neurological Society and the European Sleep Research Society.

You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medication.

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