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I was diagnosed with Restless Legs Syndrome back in the '90's. I was first prescribed levodopa/carbidopa and it was wonderful at first. However it started losing effectiveness and making me sick during the day at times. Then a new medicine came out- Mirapex and I was put on it at 0.25mg before bedtime. It worked well for several years but had to be upped to 0.5mg. I found that Mirapex controlled my RLS fairly well and I was on it for 12 years! The last year I forced myself to cut back to 0.25mg again and put up with some symptoms. Then, I recently stopped taking it altogether. I have been taking strong vitamin supplements, but they didn't stop the RLS. However, when I started taking Magnesium, Potassium, and Calcium, and bathing in bath salts the RLS has disappeared.
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Edinburgh (Scotland): Scottish Intercollegiate Guidelines Network (SIGN); 2010 Jan.
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Joints appear swollen, are stiff and painful, and usually feel worse the more they are used throughout the day.
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Speech and language therapy - improving loudness and intelligibility of speech where possible, ensuring methods of communication are available as the disease progresses and to help with swallowing (reducing risk of aspiration).
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Although the drug does provide some symptomatic relief, there is no clear evidence from this study that it offers any neuroprotection.
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Several case reports and studies involving both children and adults have provided support for the use of oral iron therapy, parenteral iron therapy, or both in the treatment of RLS.
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You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medication.
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More than one sponsor may receive orphan drug designation of the same drug for the same rare disease or condition, but each sponsor seeking orphan drug designation must file a complete request for designation as provided in paragraph (b) of this section.
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